Research in my laboratory is focused on the pathogenesis of bacterial obligate intracellular parasites (BOIPs). BOIPs encompass several genera (e.g., Anaplasma, Rickettsia, Coxiella and Chlamydia) of clinically significant pathogens, some of which are zoonotic (i.e., transmit from animals and humans). Unlike most bacteria, BOIPs require invasion of a eukaryotic host cell to reproduce and cause disease. Because BOIPs have evolved to parasitize their host cells, their genomes have undergone extensive streamlining (reduction) at the expense of metabolic capacity. Largely focused on Coxiella burnetii and Chlamydia trachomatis, we seek to understand how pathogen metabolic capacity and plasticity shape the host-pathogen interaction.
Affiliate and Adjunct Appointments
- Affiliate, School of Molecular Biosciences
Education
- PhD, University of Arizona, 2005
Research Interest
- Biological basis for specific gene loss during genome streamlining
- Developmental transitions between cells forms in Coxiella and Chlamydia
- Bacterial metabolic capacity and plasticity
- Host-pathogen interactions
- Bacterial pathogenesis
Publications
Professional Service
- WSU Radiation Safety Committee
- WSU College of Veterinary Medicine Research Committee
- WSU College of Veterinary Medicine Faculty Executive Committee
- WSU Honors College Council
- Ad hoc grant and manuscript review